Experimental diabetes exacerbates skin transplant rejection in rats
نویسندگان
چکیده
منابع مشابه
Experimental diabetes exacerbates skin transplant rejection in rats.
PURPOSE To investigate the effect of chronic experimental diabetes on skin allografts in rats as a simple model that could clarify some basic aspects and mechanisms involved in transplant rejection in diabetes compared to normal animals. METHODS Skin grafting was performed with fragments of tail skin from sex matched non diabetic Wistar rats engrafted onto the thoracic area of diabetic and no...
متن کاملMalignant skin lesions in transplant recipients
Several advances in the filed of organ transplantation in last decades have resulted in significant increase in the number and methods of transplantation. In this article various aspects of organ transplantation including immunosuppressive medications, common skin tumors seen in transplant recipients, possible mechanisms involved in increased incidence of skin tumors and finally preventive meas...
متن کاملCellular Requirements for the Rejection of Skin Allografts in Rats
The role of bone marrow-derived cells in the rejection of skin allografts in rats was investigated. Lewis rats, rendered tolerant of BN antigens and bearing healthy grafts, were thymectomized, irradiated with 900 rad, and injected with varying doses of either normal isologous bone marrow, normal lymph node cells, and/or lymph node cells presensitized to BN antigens. In some experiments rats wer...
متن کاملInterferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.
RATIONALE Transplantation, the most effective therapy for end-stage organ failure, is markedly limited by early-onset cardiovascular disease (CVD) and premature death of the host. The mechanistic basis of this increased CVD is not fully explained by known risk factors. OBJECTIVE To investigate the role of alloimmune responses in promoting CVD of organ transplant recipients. METHODS AND RESU...
متن کاملTransplant rejection in terrestrial molluscs
To know whether or not molluscs are capable of recognizing tissue allo-antigens, dorsal skin-allografts were exchanged between adult terrestrial slug, Incilaria fruhstorferi. We succeeded for the first time in orthotopic transplantation of allografts and observed chronic rejection of allografts. Cellular changes in the rejection process continued over for 40 days. Two functional types of “effec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2013
ISSN: 0102-8650
DOI: 10.1590/s0102-86502013000500001